49ers RB Christian McCaffrey exits with injury vs. Falcons, is questionable to return
Christian McCaffrey suffers thigh injury, questionable to return; other 49ers receivers also injured
WR · SF · 23 yrs · exp 0 · Ole Miss
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Latest: Oct 18, 2026 · 3,447
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Christian McCaffrey suffers thigh injury, questionable to return; other 49ers receivers also injured
The 49ers' top 4 WRs from Week 1 are inactive for the next game
The injuries continue to pile up as we are almost midway through the fantasy regular season. Below are some of the key injuries heading into Week 7. Mike Evans has played through various injuries this season. However, the 49ers are one game away from a Week 8 bye, so he will sit out this one against the Falcons, nursing rib and Achilles injuries. With the 49ers already down Ricky Pearsall , De’Zhaun Stribling, and Deebo Samuel , San Francisco’s receiving corps is barren. The 49ers will likely deploy a rotation of veteran Brandin Cooks , Jacob Cowing , Jordan Watkins , and Christian Kirk, who is set to make his 49ers debut after returning from a calf injury. All of these players are desperation starts. It’s most likely that George Kittle feasts on National Tight End Day. Lamar Jackson practiced in a limited capacity all week. He has missed the past two games with a recently disclosed high ankle sprain and will now miss a third. With Jackson out, the Ravens’ offensive players will see a dip in production as the Ravens have mustered just 429 passing yards with Jackson sidelined. Baltimore turns to Tyler Huntley, who will start for the Ravens again, hoping to improve on his lackluster performance thus far. David Montgomery will miss his second game with a groin injury. In his absence last week, Woody Marks saw a 78% snap share and finished as the RB22 on the week. Marks will continue to see the bulk of opportunities, especially since his running mate Jawhar Jordan, who saw two red-zone touches and scored a rushing touchdown last week, was placed on the practice squad Reserve/Injured list with a quadriceps injury. Passing-down specialist Dare Ogunbowale will likely spell Marks, but he remains off the fantasy radar. Emeka Egbuka is coming off two consecutive 17-point PPR performances; however, he will miss the Buccaneers’ Week 7 matchup against the Panthers with a concussion and foot injury. Veteran Chris Godwin is set to be the focal point of the Bucs’ passing offense, with Baker Mayfield set to return from a thumb injury. Godwin makes for a strong FLEX play despite his poor results thus far. Rookie Ted Hurst is also in line for increased targets with Egbuka out. Tyler Warren will miss his second straight game with a groin injury. In his absence last week, Keenan Allen saw 11 targets, and Josh Downs saw eight. Allen and Downs combined for 45% of the Colts’ targets last week. Look for both players to be featured again as the hapless Colts take on a tough Vikings defense this week. First-round rookie Jeremiyah Love will miss his second straight game with an ankle injury. In his absence last week, Zonovan Knight and Tyler Allgeier combined for 37 total opportunities, with Allgeier seeing 20 and Knight seeing 17. Both backs will likely continue to see a near-even split in backfield opportunities in a plus matchup against the Broncos. Puka Nacua popped up mid-week on the injury report with a calf injury but is officially questionable for Week 7. With Davante Adams on IR with a ruptured hamstring, Nacua will likely try to suit up for the Rams, who are in dire need of a win. Konata Mumpfield will likely join Nacua in two-WR sets in Adams’ absence but remains off the fantasy radar. Rashee Rice will miss his second straight game as he deals with hamstring and knee ailments. Xavier Worthy saw seven targets in his absence last week and led the Chiefs in targets. Worthy will look to step up again, though the Chiefs’ offense runs through Kenneth Walker. Bijan Robinson may never come off the field this week against the 49ers. However, if he does, practice squad call-up Khalil Herbert will serve as the breather back. He is a player to monitor on the wire if Brian Robinson takes some time to recover from his hamstring injury. Mason was activated from IR and is set to return from a thumb injury that sidelined him the past four weeks. He should hop right back into his role as the 1A to Aaron Jones’ 1B in the Vikings backfield. He makes for [... truncated ...]
Drops: De'Zhaun Stribling
The article outlines potential trade targets for the top eight Super Bowl‑contender teams, highlighting specific players who could address each team’s needs
Adds: De'Zhaun Stribling. Drops: Dameon Pierce
With Deebo Samuel sidelined, Brandin Cooks steps into a larger role for the 49ers' injured wide‑receiver group
Brandin Cooks likely to start Week 5 for the 49ers amid receiver injuries, offering low‑end flex value
Brock Purdy ranks second in NFL MVP odds behind Josh Allen entering his 50th career start and a showdown in Week 5 at the defending Super Bowl champions. He's been more embraced as an MVP contender in 2026 while elevating an aging and injury-prone supporting cast to a 4-0 record. It was a different story during his surprise MVP campaign in 2023, where some weaponized the term "game manager" against him. His style of play in Kyle Shanahan's system also continues to win over critics. But Sunday's game in Seattle represents a big litmus test for Purdy's MVP and superstar quarterback credentials. Purdy has been at the controls of the most efficient offense in the league this year, and he's been phenomenal himself, with a completion rate of 70%, an average of 8.9 yards per attempt, 12 total touchdowns, one turnover, and no sacks. It's about the best combination of clean football and playmaking you could dream up. It all adds up to the highest EPA per dropback (0.53) by any quarterback through four games since Tom Brady's historic 2007 season. Purdy is also the first quarterback all-time with one or fewer combined sacks, fumbles and interceptions during a 4-0 start. He sports the lowest negative play rate (0.8%) among quarterbacks through four games on record. The best part, the 49ers have been the most injured team in football this season, racking up the most games missed and IR stints in the NFL up to this point. Most of those have been on defense, but this offense could be humming even more if they had a healthy WR room, which currently has Ricky Pearsall , De'Zhaun Stribling , Demarcus Robinson and Christian Kirk on injured reserve. This sets the stage for an early MVP statement game vs. the defending champions. A win and the discourse will anoint Purdy the early-season MVP, carrying a beat-up team to a 5-0 start with wins over the Rams , Broncos, and Seahawks , three conference finalists from a year ago. A loss means the detractors will crawl out from underneath their rocks and be quick to point out that Purdy's early-season success came vs. the jetlagged Rams, Dolphins , Cardinals , and a Broncos team without its top two cornerbacks. They'll also sprinkle in the term "YAC merchant" referring to the house calls Deebo Samuel and George Kittle have made off short passes in the past two weeks. Purdy doesn't have to deal with that fake noise but there is the reality that he and the 49ers have struggled mightily with high stakes against Mike Macdonald's defense. Purdy is 2-4 in his career vs. Macdonald as the Seahawks head coach and Ravens defensive coordinator. The 49ers average just 16.3 points per game in those contests and Purdy had six touchdown passes and nine interceptions. The three worst games of Purdy's career (in terms of EPA per dropback) have come vs. Macdonald, including a Christmas nightmare in 2023 where he threw four interceptions in a blowout loss to the Ravens and eventual MVP winner Lamar Jackson . The other two games came in Week 18 last year, with home-field advantage throughout the NFC playoffs on the line, including the divisional round in Seattle. The 49ers combined to score nine points and Purdy had just one 20-yard completion in those games. They are two of the four games with fewer than seven points in Kyle Shanahan's head coaching career. Turning the tide in this rivalry won't be easy without 49ers fullback Kyle Juszczyk , who is out for a few weeks with a knee injury. He is an important chess piece in the 49ers' motion offense, especially opening up running lanes. If Purdy and co. can overcome that underrated absence and exorcise the demons against a vicious "Dark Side" defense backed by "the 12" it'll go a long way in further legitimizing Purdy's MVP campaign and status as a superstar quarterback. The latter has been cemented enough to the point where one bad game wouldn't change that in my opinion. Purdy's MVP-caliber play dates back to Week 11 last season when he returned from a nagging t [... truncated ...]
The San Francisco 49ers (3-0) face the Denver Broncos (2-1) on Sunday. The 49ers have won their games decisively, including against the Rams, Dolphins, and Cardinals. The Broncos, after an opening loss to the Chiefs, have secured wins against the Jaguars and Rams. Despite significant injuries, the 49ers' offense, highlighted by Deebo Samuel's versatile play, has remained effective. The Broncos have shown resilience, with a recent comeback victory
Brandin Cooks promoted to 49ers active roster for Week 4, filling depth amid injuries
San Francisco 49ers wide receiver Jacob Cowing should see an expanded role in Week 4, with several injuries across the team's wide receiver room. Although Cowing hasn't recorded a stat in three games this season, he's seen increased usage over the past two weeks. He's played 36% of snaps and 36% of routes. Wide receiver Mike Evans (ribs) is questionable, and De'Zhaun Stribling (ankle), Christian Kirk (calf), and Demarcus Robinson are on injured reserve. If Evans can't play, Cowing should be a key contributor alongside Deebo Samuel Sr. and Jordan Watkins. They face a difficult matchup against the Denver Broncos, who have allowed the 10th-fewest fantasy points to wide receivers this season and the second-fewest in 2025. Fantasy managers in deeper leagues should keep tabs on Cowing, especially if the 49ers suffer additional injuries to their already depleted receiver room
San Francisco 49ers add Brandin Cooks to active roster
Evans joins an injured 49ers receiver corps that already includes Ricky Pearsall and De'Zhaun Stribling
Evans joins an injured 49ers receiver corps that already features Ricky Pearsall and De'Zhaun Stribling
Mike Evans is expected to play in Sunday's game against the Cardinals despite a hip injury that caused him to miss practice time. He returned to a limited practice on Friday and plans to be in the lineup, adding to a depleted 49ers receiving corps
San Francisco 49ers wide receiver Jacob Cowing could be in line for an increased role against the Arizona Cardinals in Week 3 due to injuries within the team's wide receiver unit. Cowing has played 29 offensive snaps over two weeks and is yet to record an offensive statistic. However, with fellow wideouts Demarcus Robinson (ankle) ruled out, Mike Evans (hip) questionable, rookie De'Zhaun Stribling (ankle) on injured reserve, and Ricky Pearsall (knee) out for the season, the 49ers may be forced to rely on Cowing more in the passing game. If Evans isn't available, Cowing, Deebo Samuel, and KhaDarel Hodge, along with tight end George Kittle and running back Christian McCaffrey, could all see upticks in usage. The Cardinals are giving up 203 passing yards per game. Cowing is currently way off the radar for Week 3, checking in as RotoBaller's No. 117 wideout. He is projected to score just 2.9 fantasy points. Cowing is not a recommended start this week, but could be a stash option if the 49ers continue to get decimated by injuries in the wide receiver corps
Brandin Cooks joins 49ers practice squad, filling receiving corps void due to injuries
Drops: De'Zhaun Stribling
Jacob Cowing could step in for injured WRs on the 49ers
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