49ers RB Christian McCaffrey exits with injury vs. Falcons, is questionable to return
Christian McCaffrey suffers thigh injury, questionable to return; other 49ers receivers also injured
WR · SF · 32 yrs · exp 10 · Florida
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Latest: Sep 5, 2026 · 576
Stories linked to this player — newest first.
Christian McCaffrey suffers thigh injury, questionable to return; other 49ers receivers also injured
The 49ers' top 4 WRs from Week 1 are inactive for the next game
Drops: Demarcus Robinson
Drops: Demarcus Robinson
Drops: Demarcus Robinson
Drops: Demarcus Robinson
With Deebo Samuel sidelined, Brandin Cooks steps into a larger role for the 49ers' injured wide‑receiver group
Drops: Demarcus Robinson
Brandin Cooks likely to start Week 5 for the 49ers amid receiver injuries, offering low‑end flex value
Brock Purdy ranks second in NFL MVP odds behind Josh Allen entering his 50th career start and a showdown in Week 5 at the defending Super Bowl champions. He's been more embraced as an MVP contender in 2026 while elevating an aging and injury-prone supporting cast to a 4-0 record. It was a different story during his surprise MVP campaign in 2023, where some weaponized the term "game manager" against him. His style of play in Kyle Shanahan's system also continues to win over critics. But Sunday's game in Seattle represents a big litmus test for Purdy's MVP and superstar quarterback credentials. Purdy has been at the controls of the most efficient offense in the league this year, and he's been phenomenal himself, with a completion rate of 70%, an average of 8.9 yards per attempt, 12 total touchdowns, one turnover, and no sacks. It's about the best combination of clean football and playmaking you could dream up. It all adds up to the highest EPA per dropback (0.53) by any quarterback through four games since Tom Brady's historic 2007 season. Purdy is also the first quarterback all-time with one or fewer combined sacks, fumbles and interceptions during a 4-0 start. He sports the lowest negative play rate (0.8%) among quarterbacks through four games on record. The best part, the 49ers have been the most injured team in football this season, racking up the most games missed and IR stints in the NFL up to this point. Most of those have been on defense, but this offense could be humming even more if they had a healthy WR room, which currently has Ricky Pearsall , De'Zhaun Stribling , Demarcus Robinson and Christian Kirk on injured reserve. This sets the stage for an early MVP statement game vs. the defending champions. A win and the discourse will anoint Purdy the early-season MVP, carrying a beat-up team to a 5-0 start with wins over the Rams , Broncos, and Seahawks , three conference finalists from a year ago. A loss means the detractors will crawl out from underneath their rocks and be quick to point out that Purdy's early-season success came vs. the jetlagged Rams, Dolphins , Cardinals , and a Broncos team without its top two cornerbacks. They'll also sprinkle in the term "YAC merchant" referring to the house calls Deebo Samuel and George Kittle have made off short passes in the past two weeks. Purdy doesn't have to deal with that fake noise but there is the reality that he and the 49ers have struggled mightily with high stakes against Mike Macdonald's defense. Purdy is 2-4 in his career vs. Macdonald as the Seahawks head coach and Ravens defensive coordinator. The 49ers average just 16.3 points per game in those contests and Purdy had six touchdown passes and nine interceptions. The three worst games of Purdy's career (in terms of EPA per dropback) have come vs. Macdonald, including a Christmas nightmare in 2023 where he threw four interceptions in a blowout loss to the Ravens and eventual MVP winner Lamar Jackson . The other two games came in Week 18 last year, with home-field advantage throughout the NFC playoffs on the line, including the divisional round in Seattle. The 49ers combined to score nine points and Purdy had just one 20-yard completion in those games. They are two of the four games with fewer than seven points in Kyle Shanahan's head coaching career. Turning the tide in this rivalry won't be easy without 49ers fullback Kyle Juszczyk , who is out for a few weeks with a knee injury. He is an important chess piece in the 49ers' motion offense, especially opening up running lanes. If Purdy and co. can overcome that underrated absence and exorcise the demons against a vicious "Dark Side" defense backed by "the 12" it'll go a long way in further legitimizing Purdy's MVP campaign and status as a superstar quarterback. The latter has been cemented enough to the point where one bad game wouldn't change that in my opinion. Purdy's MVP-caliber play dates back to Week 11 last season when he returned from a nagging t [... truncated ...]
Adds: Demarcus Robinson
The San Francisco 49ers (3-0) face the Denver Broncos (2-1) on Sunday. The 49ers have won their games decisively, including against the Rams, Dolphins, and Cardinals. The Broncos, after an opening loss to the Chiefs, have secured wins against the Jaguars and Rams. Despite significant injuries, the 49ers' offense, highlighted by Deebo Samuel's versatile play, has remained effective. The Broncos have shown resilience, with a recent comeback victory
Brandin Cooks promoted to 49ers active roster for Week 4, filling depth amid injuries
San Francisco 49ers wide receiver Jacob Cowing should see an expanded role in Week 4, with several injuries across the team's wide receiver room. Although Cowing hasn't recorded a stat in three games this season, he's seen increased usage over the past two weeks. He's played 36% of snaps and 36% of routes. Wide receiver Mike Evans (ribs) is questionable, and De'Zhaun Stribling (ankle), Christian Kirk (calf), and Demarcus Robinson are on injured reserve. If Evans can't play, Cowing should be a key contributor alongside Deebo Samuel Sr. and Jordan Watkins. They face a difficult matchup against the Denver Broncos, who have allowed the 10th-fewest fantasy points to wide receivers this season and the second-fewest in 2025. Fantasy managers in deeper leagues should keep tabs on Cowing, especially if the 49ers suffer additional injuries to their already depleted receiver room
San Francisco 49ers add Brandin Cooks to active roster
Drops: Demarcus Robinson
Experts' NFL predictions and picks for Week 3, including backing Steelers and Buccaneers
SportsLine experts are backing the Steelers as underdogs against the Bengals and also see value in the Buccaneers vs. Vikings and 49ers vs. Cardinals matchups for Week 3 of the 2026 NFL season. Some experts believe the Steelers' defense can keep them competitive against the undefeated Bengals, while others point to potential vulnerabilities in the 49ers and the Buccaneers' ability to cover against the Vikings
Mike Evans is expected to play in Sunday's game against the Cardinals despite a hip injury that caused him to miss practice time. He returned to a limited practice on Friday and plans to be in the lineup, adding to a depleted 49ers receiving corps
Drops: Demarcus Robinson
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